Select Publications
2025
Structural and functional analysis of VYD222: a broadly neutralizing antibody against SARS-CoV-2 variants
Yuan M, West BR, Foreman WB, Powers C, Feng Z, Taylor AL, Yu X, Wang G, Walker L, Starr TN, Allen R, Wilson IA.
bioRxiv [Preprint]. 2025 Aug 28:2025.08.28.672883.
Replaying germinal center evolution on a quantified affinity landscape
DeWitt WS, Vora AA, Araki T, Galloway JG, Alkutkar T, Bortolatto J, Castro TBR, Dumm W, Jennings-Shaffer C, Jia T, Mesin L, Ozorowski G, Pae J, Ralph DK, Bloom JD, Nourmohammad A, Song YS, Ward AB, Starr TN, Matsen FA 4th, Victora GD.
bioRxiv [Preprint]. 2025 Jun 5:2025.06.02.656870.
Phylogeny-driven design of broadly protective sarbecovirus receptor-binding domain nanoparticle vaccines
Addetia A, Schäfer A, Sprouse K, Valdez A, Taylor A, Navarro MJ, Brown JT, Leaf EM, Miranda MC, Walls AC, Lee J, Catanzaro NJ, Treichel C, Willoughby I, Powers J, Martinez DR, Vesari B, Ravichandran R, Seo AJ, Stewart C, Merz B, Beirne E, Zepeda S, Cook A, Pessaint L, Sharma A, Edwards D, Lee K, Smith K, Starr T, Baric R, King NP, Veesler D.
bioRxiv [Preprint]. 2025 May 13:2025.05.11.652904.
2024
A potent pan-sarbecovirus neutralizing antibody resilient to epitope diversification
Rosen, LE*, MA Tortorici*, A DeMarco*, D Pinto, WB Foreman, AL Taylor, YJ Park, D Bohan, T Rietz, JM ERrico, K Hauser, HV Dang, JW Chartoron, M Giurdanella, G Cusumano, C Saliba, F Zatta, KR Sprouse, A Addetia, SK Zepeda, JT Brown, J Lee, E Dellta Jr, A Rajesh, J Noack, Q Tao, Y DaCosta, B Tsu, R Acosta, S Subramanian, GD de Melo, L Kergoat, I Zhang, Z Liu, B Guarino, MA Schmid, G Schnell, JL Miller, FA Lempp, N Czudnochowski, E Cameroni, SPJ Whelan, H Bourhy, LA Purcell, F Benigni, J di Iulio, MS Piuzzuto, A Lanzavecchia, A Telenti, G Snell, D Corti†, D Veesler†, TN Starr†.
Cell 127(85):7196-7213.E26.
Deep mutational scanning of SARS-CoV-2 Omicron BA.2.86 and epistatic emergence of the KP.3 variant
Taylor, AL, TN Starr†.
VIrus Evolution 10(1):veae067.
Isolation and escape mapping of broadly neutralizing antibodies against emerging delta-coronaviruses
M Rexhepaj, D Asarnow, L Perruzza, YJ Park, B Guarino, M Mccallum, K Culap, C Saliba, G Leoni, A Balmelle, C Yoshiyama, MS Dickinson, J Quispe, JT Brown, MA Tortorici, KR Sprouse, AL Taylor, D Corti, TN Starr†, F Benigni†, D Veesler†
Immunity 57(12):2914-2927.E7.
Delineating the functional activity of antibodies with cross-reactivity to SARS-CoV-2, SARS-CoV-1 and related sarbecoviruses
Ruiz, F*, WB Foreman*, M Lilly, VA Baharani, DM Depierreux, V Chohan, AL Taylor, J Guenthoer, D Ralph, FA Matsen IV, HY Chu, PD Bieniasz, M Cote, TN Starr†, J Overbaugh†.
PLOS Pathogens 20c(10):e1012650
2023
Deep mutational scans of XBB.1.5 and BQ.1.1 reveal ongoing epistatic drift during SARS-CoV-2 evolution
Taylor, AL, TN Starr.
PLOS Pathogens 19(12):e1011901.
Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus
Lee, J, SK Zepeda, YJ Park, AL Taylor, J Quispe, C Stewart, EM LEaf, C Treicel, D Corti, NP King, TN Starr, D Veesler.
Cell Host & Microbe 31:19661-1973.
2022
ACE2 binding is an ancestral and evolvable trait of sarbecoviruses
Starr, TN*,†, SK Zepeda*, AC Walls, AJ Greaney, D Veesler†, JD Bloom†.
Nature 603:913-918.
Featured on This Week in Virology and BBC Science in Action podcasts
Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution
Starr, TN*,†, AJ Greaney*, WW Hannon, AN Loes, K Hauser, JR Dillen, E Ferri, A Ghez Farrell, B Dadonaite, M McCallum, KA Matreyek, D Corti, D Veesler, G Snell, JD Bloom†.
Science 377:420-424.
Deep mutational scans for ACE2 binding, RBD expression, and antibody escape in the SARS-CoV-2 Omicron BA.1 and BA.2 receptor-binding domains
Starr, TN*,†, AJ Greaney*, CM Stewart, AC Walls, WW Hannon, D Veesler, JD Bloom†.
PLOS Pathogens 18:e1010951.
Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry
Park, Y-J*, A De Marco*, TN Starr*, Z Liu*, D Pinto, AC Walls, F Zatta, SK Zepeda, JE Bowen, KR Sprouse, A Joshi, M Giurdanella, B Guarino, J Noack, R Abdelnabi, SC Foo, LE Rosen, FA Lempp, F Benigni, G Snell, J Neyts, SPJ Whelan, HW Virgin, JD Bloom, D Corti, MS Pizzuto, D Veesler.
Science 375:449-454.
2021
SARS-CoV-2 RBD antibodies that maximize breadth and resistance to viral escape
Starr, TN*, N Czudnochowski*, Z Liu*, F Zatta, YJ Park, A Addetia, D Pino, M Beltramello, P Hernandez, AJ Greaney, R Marzi, WG Glass, I Zhang, AS Dingens, JE Bowen, MA Tortorici, AC Walls, JA Wojcechowskyj, A De Marco, LE Rosen, J Zhou, M Montiel-Ruiz, H Kaiser, JR Dillen, H Tucker, J Bassi, C Silacci-Fregni, MP Housley, J di Iulio, G Lombardo, M Agostini, N Sprugasci, K Culap, S Jaconi, M Meury, E Dellota Jr, R Abdelnabi, SC Foo, E Cameroni, S Stumpf, TI Croll, JC Nix, C Havenar-Daughton, L Piccoli, F Benigni, J Neyts, A Telenti, FA Lempp, MS Pizzuto, JD Chodera, CM Hebner, HW Virgin, SPJ Whelan, D Veesler, D Corti, JD Bloom, G Snell.
Nature 597:97-102.
Prospective mapping of viral mutations that escape antibodies used to treat COVID-19
Starr, TN*, AJ Greaney*, A Addetia, WW Hannon, MC Choudhary, AS Dingens, JZ Li, JD Bloom.
Science 371(6531):850-854.
Featured on NIH Director’s Blog
Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016.
Starr, TN, AJ Greaney, AS Dingens, JD Bloom.
Cell Reports Medicine, 2(4):100255.
Broad sarbecovirus neutralization by a human monoclonal antibody
Tortorici, MA*, N Czudnochowski*, TN Starr*, R Marzi*, AC Walls, F Zatta, JE Bowen, S Jaconi, J di Iulio, Z Wang, A De Marco, SK Zepeda, D Pinto, Z Liu, M Beltramello, I Bartha, MP Housley, FA Lempp, LE Rosen, E Dellota Jr, H Kaiser, M Montiel-Ruiz, J Zhou, A Addetia, B Guarino, K Culap, N Sprugasci, C Saliba, E Vetti, I Giacchetto-Sasselli, CS Fregni, R Abdelnabi, SC Foo, C Havenar-Daughton, MA Schmid, F Benigni, E Cameroni, J Neyts, A Telenti, HW Virgin, SPJ Whelan, G Snell, JD Bloom, D Corti, D Veesler, MS Pizzuto.
Nature 597:103-108.
Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition
Greaney, AJ*, TN Starr*, P Gilchuk*, SJ Zost*, E Binshtein, AN Loes, SK Hilton, J Huddleston, R Eguia, KHD Crawford, AS Dingens, RS Nargi, RE Sutton, N Suryadevara, PW Rothlauf, Z Liu, SPJ Whelan, RH Carnahan, JE Crowe Jr, JD Bloom.
Cell Host & Microbe 29(1):44-57.
2020
Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
Starr, TN*, AJ Greaney*, SK Hilton, D Ellis, KHD Crawford, AS Dingens, MJ Navarro, JE Bowen, MA Tortorici, AC Walls, NP King, D Veesler, JD Bloom.
Cell 182(5):1295-1310.
Featured on Science Translational Medicine “In the Pipeline”
Interviewed on This Week in Evolution podcast
Featured in Quanta Magazine
2018
Pervasive contingency and irreversibility in a billion years of Hsp90 evolution
Starr, TN*, JM Flynn*, P Mishra*, DNA Bolon, JW Thornton.
PNAS, 115(17):4453-4458.
2017
Alternative evolutionary histories in the sequence space of an ancient protein
Starr, TN, LK Picton, JW Thornton.
Nature, 549:409-413.
2016
Epistasis in protein evolution
Starr, TN, JW Thornton.
Protein Science, 25(7):1204-1218.