Select Publications

2024

A potent pan-sarbecovirus neutralizing antibody resilient to epitope diversification

Rosen, LE*, MA Tortorici*, A DeMarco*, D Pinto, WB Foreman, AL Taylor, YJ Park, D Bohan, T Rietz, JM ERrico, K Hauser, HV Dang, JW Chartoron, M Giurdanella, G Cusumano, C Saliba, F Zatta, KR Sprouse, A Addetia, SK Zepeda, JT Brown, J Lee, E Dellta Jr, A Rajesh, J Noack, Q Tao, Y DaCosta, B Tsu, R Acosta, S Subramanian, GD de Melo, L Kergoat, I Zhang, Z Liu, B Guarino, MA Schmid, G Schnell, JL Miller, FA Lempp, N Czudnochowski, E Cameroni, SPJ Whelan, H Bourhy, LA Purcell, F Benigni, J di Iulio, MS Piuzzuto, A Lanzavecchia, A Telenti, G Snell, D Corti†, D Veesler†, TN Starr†.

Cell 127(85):7196-7213.E26.

Deep mutational scanning of SARS-CoV-2 Omicron BA.2.86 and epistatic emergence of the KP.3 variant

Taylor, AL, TN Starr†.

VIrus Evolution 10(1):veae067.

Isolation and escape mapping of broadly neutralizing antibodies against emerging delta-coronaviruses

M Rexhepaj, D Asarnow, L Perruzza, YJ Park, B Guarino, M Mccallum, K Culap, C Saliba, G Leoni, A Balmelle, C Yoshiyama, MS Dickinson, J Quispe, JT Brown, MA Tortorici, KR Sprouse, AL Taylor, D Corti, TN Starr†, F Benigni†, D Veesler†

Immunity 57(12):2914-2927.E7.

Delineating the functional activity of antibodies with cross-reactivity to SARS-CoV-2, SARS-CoV-1 and related sarbecoviruses

Ruiz, F*, WB Foreman*, M Lilly, VA Baharani, DM Depierreux, V Chohan, AL Taylor, J Guenthoer, D Ralph, FA Matsen IV, HY Chu, PD Bieniasz, M Cote, TN Starr†, J Overbaugh†.

PLOS Pathogens 20c(10):e1012650

2023

Deep mutational scans of XBB.1.5 and BQ.1.1 reveal ongoing epistatic drift during SARS-CoV-2 evolution

Taylor, AL, TN Starr.

PLOS Pathogens 19(12):e1011901.

Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus

Lee, J, SK Zepeda, YJ Park, AL Taylor, J Quispe, C Stewart, EM LEaf, C Treicel, D Corti, NP King, TN Starr, D Veesler.

Cell Host & Microbe 31:19661-1973.

2022

ACE2 binding is an ancestral and evolvable trait of sarbecoviruses

Starr, TN*,†, SK Zepeda*, AC Walls, AJ Greaney, D Veesler†, JD Bloom†.

Nature 603:913-918.

Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution

Starr, TN*,†, AJ Greaney*, WW Hannon, AN Loes, K Hauser, JR Dillen, E Ferri, A Ghez Farrell, B Dadonaite, M McCallum, KA Matreyek, D Corti, D Veesler, G Snell, JD Bloom†.

Science 377:420-424.

Deep mutational scans for ACE2 binding, RBD expression, and antibody escape in the SARS-CoV-2 Omicron BA.1 and BA.2 receptor-binding domains

Starr, TN*,†, AJ Greaney*, CM Stewart, AC Walls, WW Hannon, D Veesler, JD Bloom†.

PLOS Pathogens 18:e1010951.

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

Park, Y-J*, A De Marco*, TN Starr*, Z Liu*, D Pinto, AC Walls, F Zatta, SK Zepeda, JE Bowen, KR Sprouse, A Joshi, M Giurdanella, B Guarino, J Noack, R Abdelnabi, SC Foo, LE Rosen, FA Lempp, F Benigni, G Snell, J Neyts, SPJ Whelan, HW Virgin, JD Bloom, D Corti, MS Pizzuto, D Veesler.

Science 375:449-454.

2021

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to viral escape

Starr, TN*, N Czudnochowski*, Z Liu*, F Zatta, YJ Park, A Addetia, D Pino, M Beltramello, P Hernandez, AJ Greaney, R Marzi, WG Glass, I Zhang, AS Dingens, JE Bowen, MA Tortorici, AC Walls, JA Wojcechowskyj, A De Marco, LE Rosen, J Zhou, M Montiel-Ruiz, H Kaiser, JR Dillen, H Tucker, J Bassi, C Silacci-Fregni, MP Housley, J di Iulio, G Lombardo, M Agostini, N Sprugasci, K Culap, S Jaconi, M Meury, E Dellota Jr, R Abdelnabi, SC Foo, E Cameroni, S Stumpf, TI Croll, JC Nix, C Havenar-Daughton, L Piccoli, F Benigni, J Neyts, A Telenti, FA Lempp, MS Pizzuto, JD Chodera, CM Hebner, HW Virgin, SPJ Whelan, D Veesler, D Corti, JD Bloom, G Snell.

Nature 597:97-102.

Prospective mapping of viral mutations that escape antibodies used to treat COVID-19

Starr, TN*, AJ Greaney*, A Addetia, WW Hannon, MC Choudhary, AS Dingens, JZ Li, JD Bloom.

Science 371(6531):850-854.

Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016.

Starr, TN, AJ Greaney, AS Dingens, JD Bloom.

Cell Reports Medicine, 2(4):100255.

Broad sarbecovirus neutralization by a human monoclonal antibody

Tortorici, MA*, N Czudnochowski*, TN Starr*, R Marzi*, AC Walls, F Zatta, JE Bowen, S Jaconi, J di Iulio, Z Wang, A De Marco, SK Zepeda, D Pinto, Z Liu, M Beltramello, I Bartha, MP Housley, FA Lempp, LE Rosen, E Dellota Jr, H Kaiser, M Montiel-Ruiz, J Zhou, A Addetia, B Guarino, K Culap, N Sprugasci, C Saliba, E Vetti, I Giacchetto-Sasselli, CS Fregni, R Abdelnabi, SC Foo, C Havenar-Daughton, MA Schmid, F Benigni, E Cameroni, J Neyts, A Telenti, HW Virgin, SPJ Whelan, G Snell, JD Bloom, D Corti, D Veesler, MS Pizzuto.

Nature 597:103-108.

Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition

Greaney, AJ*, TN Starr*, P Gilchuk*, SJ Zost*, E Binshtein, AN Loes, SK Hilton, J Huddleston, R Eguia, KHD Crawford, AS Dingens, RS Nargi, RE Sutton, N Suryadevara, PW Rothlauf, Z Liu, SPJ Whelan, RH Carnahan, JE Crowe Jr, JD Bloom.

Cell Host & Microbe 29(1):44-57.

2020

Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding

Starr, TN*, AJ Greaney*, SK Hilton, D Ellis, KHD Crawford, AS Dingens, MJ Navarro, JE Bowen, MA Tortorici, AC Walls, NP King, D Veesler, JD Bloom.

Cell 182(5):1295-1310.

2018

Pervasive contingency and irreversibility in a billion years of Hsp90 evolution

Starr, TN*, JM Flynn*, P Mishra*, DNA Bolon, JW Thornton.

PNAS, 115(17):4453-4458.

2017

Alternative evolutionary histories in the sequence space of an ancient protein

Starr, TN, LK Picton, JW Thornton.

Nature, 549:409-413.

2016

Epistasis in protein evolution

Starr, TN, JW Thornton.

Protein Science, 25(7):1204-1218.